Is the whole greater than the sum of its parts?

So the trend seems to be leaning towards the use of supplements comprised of herbal ingredients, which are considered (generally) safer than some of the more well-known prescription-based alternatives -- which might be more potent but also carry a higher risk of undesirable side effects.

Some companies market supplements formulated with a bunch of different “all-natural” ingredients, with a particular emphasis on select ingredients like Yohimbe Bark Extract and Tribulus Terrestris -- and then there are the rest, which might be considered “fillers.”

Do these extraneous components even serve a purpose that yields tangible results? Or would we be better off taking pure forms of Yohimbe, Tribulus, etc.? A product like ActiGain™ supposedly contains Tribulus, Green Tea Extract and a handful of other familiar and perhaps not-so-familiar ingredients. And the verdict is ... ?